The term osteomyelitis encompasses a broad group of infectious diseases characterized by infection of the bone and/or bone marrow. The pathogenesis of these diseases can follow acute, subacute or chronic courses and involves a range of contributory host and pathogen factors. A commonly used aetiological classification distinguishes between three types of osteomyelitis: acute or chronic haematogenous disease seeded by organisms in the bloodstream, local spread from a contiguous source of infection and secondary osteomyelitis related to vascular insufficiency. Risk factors, such as systemic or local immunocompromise and prosthetic implantation, can increase one’s risk for infection. The unique demarcated environment of osteomyelitis results in a high-grade local inflammatory host response leading to formation of sequestrum. This report discus a case of chronic focal sclerosing osteomyelitis with a history of drug therapy leading to an immunocompromised state systemically.
Keywords: Osteomyelitis , Bone Scleroses, Sequestrum.